Methanol → HCID 178501209, compound

HRID 1007290Notes

Reaction equation

HRID 1007290 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8]([C@H:5]1[CH2:6][CH2:7][C@@H:2]([NH2:1])[CH2:3][CH2:4]1)=[O:10]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511566HCID 178511566, compound

Product 1

HCID 178501209HCID 178501209, compound

Procedure

A solution of 2.0 g of cis-4-aminocyclohexanecarboxylic acid in 20 mL of methanol was combined with 3.57 mL of thionyl chloride, and stirred for 3 hours. The reaction solution was concentrated, and the residue was washed with ethyl ether to obtain 2.64 g of the desirable compound as colorless crystals.

Workup

  1. concentrationThe reaction solution was concentrated
  2. washthe residue was washed with ethyl ether

Sources & evidence

ORD record
ord-045e3cd6d56142f994399d3401151979
Source dataset
uspto-grants-2004_09
Patent number
US06794389B2

Reaction notes

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