Ammonium Chloride → HCID 86591098, compound

HRID 1007311Notes

Reaction equation

C[Al](C)C.[Cl-].[NH4+:6].[C:7]1([C:13]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:14]2[CH:18]=[C:17]([C@@H:19]3[CH2:21][C@H:20]3[C:22]#[N:23])[N:16]=[CH:15]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1(C)C=CC=CC=1.C(Cl)(Cl)Cl>[C:30]1([C:13]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:14]2[CH:18]=[C:17]([C@@H:19]3[CH2:21][C@H:20]3[C:22](=[NH:6])[NH2:23])[N:16]=[CH:15]2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

Conditions

Temperature: 25 °C

Procedure

A solution of trimethylaluminium in toluene (2M, 0.6 mL, 1.2 mmol) was slowly added to a suspension of ammonium chloride (64 mg, 12 mmol) in dry toluene (5 mL) at 0° C. under nitrogen. The resulting mixture was warmed to 25° C. and stirred for 3 hours until gas evolution had ceased. Then, N-triphenylmethyl-4-(trans-2-cyano-cyclopropyl)imidazole (200 mg, 0.53 mmol) in dry toluene (10 mL) was added and the reaction mixture was heated to 80° C. for 18 hours under nitrogen, slowly poured into a slurry of silica gel (15 g) in chloroform (50 mL), and stirred for 10 minutes. The silica was filtered and washed with methanol. The combined solvent mixture was concentrated under vacuum and the residue was purified on a silica gel column using 85/15/5 (v/v/v) methylene chloride/methanol/ammonium hydroxide as the eluent to give a white solid (140 mg, 68% yield).

Workup

temperaturethe reaction mixture was heated to 80° C. for 18 hours under nitrogen
stirringstirred for 10 minutes
filtrationThe silica was filtered
washwashed with methanol
concentrationThe combined solvent mixture was concentrated under vacuum
customthe residue was purified on a silica gel column

Sources & evidence

ORD record: ord-1ab57edb8e72427ba7178d5477a07a0c
Source dataset: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06794405B2

Reaction notes

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