Trifluoroacetic acid → HCID 178525675, compound

Participants

Reaction Steps

A mixture of N-triphenylmethyl-4-(trans-2-hydroxymethyl-cyclopropyl)imidazole (100 mg, 0.26 mmol) and trifluoroacetic acid (TFA) (10 mL) was stirred at room temperature for 1-3 hours. The TFA was evaporated under reduced pressure. The resulting mixture was diluted with distilled water (5 mL) and extracted with ether (3×15 mL). The aqueous layer was lyophilized to give the product (61 mg, 93% yield).

Provenance & Evidence