Trifluoroacetic acid → HCID 178525675, compound

HRID 1007313Notes

Reaction equation

HRID 1007313 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([C@@H:13]3[CH2:15][C@H:14]3[CH2:16][OH:17])[N:10]=[CH:9]2)C=CC=CC=1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[OH:17][CH2:16][C@@H:14]1[CH2:15][C@H:13]1[C:11]1[N:10]=[CH:9][NH:8][CH:12]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10992545HCID 10992545, compound

Product 1

HCID 178525675HCID 178525675, compoundYield 93%

Procedure

A mixture of N-triphenylmethyl-4-(trans-2-hydroxymethyl-cyclopropyl)imidazole (100 mg, 0.26 mmol) and trifluoroacetic acid (TFA) (10 mL) was stirred at room temperature for 1-3 hours. The TFA was evaporated under reduced pressure. The resulting mixture was diluted with distilled water (5 mL) and extracted with ether (3×15 mL). The aqueous layer was lyophilized to give the product (61 mg, 93% yield).

Workup

  1. customThe TFA was evaporated under reduced pressure
  2. additionThe resulting mixture was diluted with distilled water (5 mL)
  3. extractionextracted with ether (3×15 mL)

Sources & evidence

ORD record
ord-fbcb21d6cedf49ee8c337acb87e3f091
Source dataset
uspto-grants-2004_09
Patent number
US06794405B2

Reaction notes

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