m-(Trifluoromethyl)nitrobenzene → HCID 69744202, compound

HRID 1007374Notes

Reaction equation

HRID 1007374 reaction equation
[K].CC(C)([O-])C.[N+:7]([C:10]1[CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:14][CH:15]=1)([O-:9])=[O:8].Cl[CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>CN(C)C=O>[N+:7]([C:10]1[CH:11]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:13]=[CH:14][C:15]=1[CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])([O-:9])=[O:8]

Participants

5

Reactant 3

HCID 7386m-(Trifluoromethyl)nitrobenzeneHCID 66052tert-Butyl chloroacetateHCID 50987170Potassium tertbutoxide

Product 1

HCID 69744202HCID 69744202, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

2.6 g of potassium-tert.butoxide are placed in 45 ml of dimethylformamide and at an internal temperature of −5° C. 1.3 ml of 3-nitro-trifluorotoluene and 1.5 ml of tert.butyl chloroacetate in 1 ml of dimethylformamide are added dropwise. The mixture is stirred for another 5 minutes and the solution is then poured onto ice water and the precipitate formed is suction filtered.

Workup

  1. additionthe solution is then poured onto ice water
  2. customthe precipitate formed
  3. filtrationfiltered

Sources & evidence

ORD record
ord-c179755f1dae42e8b872fbfe5aef5b41
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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