Hydrochloric Acid → HCID 178486530, compound

HRID 1007451Notes

Reaction equation

HRID 1007451 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][C:14]2[CH:41]=[CH:40][C:17]([NH:18]/[C:19](=[C:26]3\[C:27](=[O:39])[NH:28][C:29]4[C:34]\3=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=4)/[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[C:4]([CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([NH:18]/[C:19](=[C:26]3\[C:27](=[O:39])[NH:28][C:29]4[C:34]\3=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=4)/[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:40][CH:41]=2)[CH2:10][CH2:11]1)([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469218HCID 178469218, compound

Product 1

HCID 178486530HCID 178486530, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

0.4 g of 3-(Z)-(1-{4-[2-(4-ethoxycarbonyl-piperidin-1-yl)-ethyl]-anilino}-1-phenyl-methylidene)-5,6-dimethoxy-2-indolinone are dissolved in 8.0 ml of ethanol and 2.0 ml of 1N sodium hydroxide solution are added. The mixture is stirred for 1 hour at 50° C. 2.0 ml of 1N HCl are added to the clear solution and the precipitate formed is suction filtered. The precipitate is washed with water and ethanol and dried in vacuo at 100° C.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washThe precipitate is washed with water and ethanol
  4. customdried in vacuo at 100° C.

Sources & evidence

ORD record
ord-0c6665c5bbd24e688a408583beefd91d
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

Loading…