HRID1007451

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

$结构：CCOC(=O)C1CCN(CCc2ccc(N/C(=C3\C(=O)Nc4cc(OC)c(OC)cc43)c3ccccc3)cc2)CC1$

HCID178469218

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(cc1OC)/C(=C(/Nc1ccc(CCN3CCC(C(=O)O)CC3)cc1)c1ccccc1)C(=O)N2

HCID178486530

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 50 °C

PROCEDURE

实验过程

0.4 g of 3-(Z)-(1-{4-[2-(4-ethoxycarbonyl-piperidin-1-yl)-ethyl]-anilino}-1-phenyl-methylidene)-5,6-dimethoxy-2-indolinone are dissolved in 8.0 ml of ethanol and 2.0 ml of 1N sodium hydroxide solution are added. The mixture is stirred for 1 hour at 50° C. 2.0 ml of 1N HCl are added to the clear solution and the precipitate formed is suction filtered. The precipitate is washed with water and ethanol and dried in vacuo at 100° C.

WORKUP

后处理

customthe precipitate formed
filtrationfiltered
washThe precipitate is washed with water and ethanol
customdried in vacuo at 100° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c6665c5bbd24e688a408583beefd91d
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06794395B1
来源说明: uspto-grants-2004_09

反应 SMILES

C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][C:14]2[CH:41]=[CH:40][C:17]([NH:18]/[C:19](=[C:26]3\[C:27](=[O:39])[NH:28][C:29]4[C:34]\3=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=4)/[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[C:4]([CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([NH:18]/[C:19](=[C:26]3\[C:27](=[O:39])[NH:28][C:29]4[C:34]\3=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=4)/[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:40][CH:41]=2)[CH2:10][CH2:11]1)([OH:5])=[O:3]