HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178486529, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 178486530 | HCID 178486530 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Product | HCID 178486529 | HCID 178486529 | — |
Reaction Steps
0.2 g of 3-(Z)-(1-{4-[2-(4-carboxy-piperidin-1-yl)-ethyl]-anilino}-1-phenyl-methylidene)-5,6-dimethoxy-2-indolinone are dissolved in 5.0 ml of dimethylformamide and 0.2 g of TBTU, 0.1 g of HOBT and 0.5 ml of triethylamine are added. Finally 0.2 g of dimethylamine hydrochloride are added and the mixture is stirred for 2 hours at ambient temperature. The solvent is eliminated and the residue is stirred with water, suction filtered and washed with isopropanol and ether. The residue is dried in vacuo at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794395B1 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-d63b626c053f40ee9a5e847e9188b8f5 |
| Source note | uspto-grants-2004_09 |