Triethylamine → HCID 178486529, compound

HRID 1007452Notes

Reaction equation

HRID 1007452 reaction equation
[C:1]([CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][C:12]2[CH:39]=[CH:38][C:15]([NH:16]/[C:17](=[C:24]3\[C:25](=[O:37])[NH:26][C:27]4[C:32]\3=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=4)/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(O)=[O:2].C1C=CC2N(O)N=NC=2C=1.[CH2:50]([N:52](CC)[CH2:53]C)C.Cl.CNC>CN(C)C=O.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.O>[CH3:50][N:52]([CH3:53])[C:1]([CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][C:12]2[CH:39]=[CH:38][C:15]([NH:16]/[C:17](=[C:24]3\[C:25](=[O:37])[NH:26][C:27]4[C:32]\3=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=4)/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)=[O:2]

Participants

8

Reactant 4

HCID 8471TriethylamineHCID 10473Dimethylamine, hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 178486530HCID 178486530, compound

Product 1

HCID 178486529HCID 178486529, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateSolvent

Procedure

0.2 g of 3-(Z)-(1-{4-[2-(4-carboxy-piperidin-1-yl)-ethyl]-anilino}-1-phenyl-methylidene)-5,6-dimethoxy-2-indolinone are dissolved in 5.0 ml of dimethylformamide and 0.2 g of TBTU, 0.1 g of HOBT and 0.5 ml of triethylamine are added. Finally 0.2 g of dimethylamine hydrochloride are added and the mixture is stirred for 2 hours at ambient temperature. The solvent is eliminated and the residue is stirred with water, suction filtered and washed with isopropanol and ether. The residue is dried in vacuo at 100° C.

Workup

  1. filtrationfiltered
  2. washwashed with isopropanol and ether
  3. customThe residue is dried in vacuo at 100° C.

Sources & evidence

ORD record
ord-d63b626c053f40ee9a5e847e9188b8f5
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

Loading…