Hydrochloric Acid → HCID 178525860, compound

HRID 1007465Notes

Reaction equation

HRID 1007465 reaction equation
C[O:2][C:3]([CH2:5][NH:6][C:7]1[CH:15]=[C:14]2[C:10](/[C:11](=[C:17](/[NH:24][C:25]3[CH:30]=[CH:29][C:28]([CH2:31][N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[CH:27][CH:26]=3)\[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)/[C:12](=[O:16])[NH:13]2)=[CH:9][CH:8]=1)=[O:4].[OH-].[Na+].Cl>CO.C(Cl)Cl>[C:3]([CH2:5][NH:6][C:7]1[CH:15]=[C:14]2[C:10](/[C:11](=[C:17](/[NH:24][C:25]3[CH:26]=[CH:27][C:28]([CH2:31][N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[CH:29][CH:30]=3)\[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)/[C:12](=[O:16])[NH:13]2)=[CH:9][CH:8]=1)([OH:4])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178501554HCID 178501554, compound

Product 1

HCID 178525860HCID 178525860, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

180 mg of 6-methoxycarbonylmethylamino-3-(Z)-{1-[4-(piperidin-1-yl-methyl)-anilino]-1-phenyl-methylidene}-2-indolinone are placed in 10 ml of methanol, 1.0 ml of 1N sodium hydroxide solution are added and the mixture is stirred for 1 hour at 40° C. After cooling it is neutralised with 1.0 ml of 1N hydrochloric acid and the solvent is eliminated. The residue is dissolved in methylene chloride and a little methanol and dried over sodium sulphate.

Workup

  1. temperatureAfter cooling it
  2. dry with materiala little methanol and dried over sodium sulphate

Sources & evidence

ORD record
ord-12fd58c27e414ef8af329adc285cae8e
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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