反应详情

Analogously to the procedure of Example V, 10.0 g (57.07 mmol) of 5-hydroxy-3-isopropylindole are dissolved in 300 ml of DMSO, 8.68 g (62.77 mmol) of potassium carbonate are added, the mixture is stirred for 10 min at room temperature and 11.95 g (57.07 mmol) of 4,5,6-trichlorobenzaldehyde are introduced in portions, and the mixture is additionally stirred for 2 hours at room temperature and 2 hours at 50° C. After quenching with ethyl acetate/ammonium chloride solution and silica gel chromatography by means of toluene, 12,01 g (85,4%) of the desired product are obtained.

1. stirringthe mixture is additionally stirred for 2 hours at room temperature and 2 hours at 50° C
2. customAfter quenching with ethyl acetate/ammonium chloride solution and silica gel chromatography by means of toluene, 12,01 g (85,4%) of the desired product
3. customare obtained