HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Triphenylphosphine dibromide | HCID 70579 | — |
| Reactant | 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl alcohol | HCID 60110693 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl bromide | HCID 22669624 | — |
Reaction Steps
Analogously to the procedure of Example VII, 4.8 g (12.66 mmol) of benzyl alcohol derivative from Example XVII are reacted with 6.95 g (16.46 mmol) of dibromotriphenylphosphorane and 1.6 g (20.26 mmol) of pyridine in 80 ml of acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794406B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-ef6325c587d84de9b88dfe3628878e82 |
| Source note | uspto-grants-2004_09 |