反应详情

Analogously to the procedure of Example V, 2.0 g (8.72 mmol) of 5-hydroxy-3-cyclohexylmethyl-indole are dissolved in 50 ml of DMSO, 1.33 g (9.59 mmol) of potassium carbonate are added, the mixture is stirred for 10 min at room temperature and afterwards 2.41 g (8.72 mmol) of 3,5-bis-trifluoromethyl-4-chlorobenzaldehyde are introduced in portions. After stirring overnight at 50° C., the batch is worked up analogously to Example V and the crude product is chromatographed on silica gel 60 by means of toluene.

1. stirringAfter stirring overnight at 50° C.
2. customthe crude product is chromatographed on silica gel 60 by means of toluene