Potassium Hydroxide → HCID 23668094, compound

HRID 1007499Notes

Reaction equation

HRID 1007499 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:22][C:23](=[O:28])[CH2:24][C:25]([OH:27])=[O:26])[CH:5]=[C:6]([CH3:21])[C:7]=1[O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH:18]([CH3:20])[CH3:19].[OH-].[K+:30]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:22][C:23](=[O:28])[CH2:24][C:25]([O-:27])=[O:26])[CH:5]=[C:6]([CH3:21])[C:7]=1[O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH:18]([CH3:19])[CH3:20].[K+:30]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10294443HCID 10294443, compound

Product 1

HCID 23668094HCID 23668094, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.16 g (2.89 mmol) of 3-({3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methyl-phenyl}amino)-3-oxopropionic acid (Example 6) are dissolved in 15 ml of THF and treated dropwise at 0° C. with 5.67 ml of a 0.51 molar potassium hydroxide solution. The reaction mixture is stirred for one hour and the solvent is then removed in vacuo. By co-evaporation with toluene, 1.25 g (99% of theory) of potassium 3-({3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methylphenyl}-amino)-3-oxopropanoate are obtained

Workup

  1. customthe solvent is then removed in vacuo

Sources & evidence

ORD record
ord-4e8f06de006d457fa9019ae6f7eee9a8
Source dataset
uspto-grants-2004_09
Patent number
US06794406B2

Reaction notes

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