反应详情

1.0 g (2.41 mmol) of aldehyde derivative from Example V is dissolved in 10 ml of toluene and 0.92 g (2.65 mmol) of ethoxycarbonylmethylene-triphenylphosphorane is introduced in portions. After stirring at room temperature for 2 days, the reaction mixture is concentrated to a half of the volume and chromatographed on silica gel 60 by means of toluene.

1. concentrationthe reaction mixture is concentrated to a half of the volume
2. customchromatographed on silica gel 60 by means of toluene