HCID 86587751, compound → HCID 22669529, compound

HRID 1007513Notes

Reaction equation

HRID 1007513 reaction equation
[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([CH:24]=[CH:25][C:26](=[O:34])[CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:16][C:15]=3[C:35]([F:38])([F:37])[F:36])[CH:11]=2)[NH:6][CH:5]=1)([CH3:3])[CH3:2]>CO.[Pd]>[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([CH2:24][CH2:25][C:26](=[O:34])[CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:16][C:15]=3[C:35]([F:38])([F:36])[F:37])[CH:11]=2)[NH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86587751HCID 86587751, compound

Product 1

HCID 22669529HCID 22669529, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Analogously to the procedure of Example 25, 0.2 g (0.38 mmol) of 3-oxopentene-4-Carboxylic acid derivative from Example 26 is hydrogenated overnight in methanol with palladium on active carbon under a hydrogen atmosphere. The crude product is chromatographed on silica gel using toluene/ethyl acetate (10:1) in the isocratic mode.

Workup

  1. customThe crude product is chromatographed on silica gel

Sources & evidence

ORD record
ord-f7784b8fa119432d8fb8fd268eb35508
Source dataset
uspto-grants-2004_09
Patent number
US06794406B2

Reaction notes

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