Ammonium Hydroxide → HCID 9899303, compound

HRID 1007699Notes

Reaction equation

HRID 1007699 reaction equation
Cl.CO[C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[OH-].[NH4+:20]>>[OH:17][C:14]1[CH:15]=[C:16]2[C:11]([NH:10][CH:9]=[C:8]2[CH2:7][C@@H:5]([C:4]([NH2:20])=[O:18])[NH2:6])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 24802218methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride

Product 1

HCID 9899303HCID 9899303, compound

Procedure

(S)-5-Hydroxytryptophan methyl ester hydrochloride (0.247 g, 0.91 mmol) was stirred overnight at room temperature in ammonium hydroxide (10 mL). After removal of volatiles under vacuum, the title compound of example 44 was obtained as a dark solid.

Workup

  1. customAfter removal of volatiles under vacuum

Sources & evidence

ORD record
ord-e1014672ce81403e92305650bdc5495f
Source dataset
uspto-grants-2004_09
Patent number
US06794404B2

Reaction notes

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