HRID1007733

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID60984

Methyl bromoacetate

C3H5BrO2

结构：Cc1cc2c(cc1C(=O)O)nc(-c1ccoc1)n2C1CCCCC1

HCID3012619

未命名化合物

结构：COC(=O)[C@@H](N)Cc1c[nH]c2ccc(O)cc12.Cl

HCID24802218

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2c(cc1C(=O)N[C@@H](Cc1c[nH]c3ccc(OCC(=O)O)cc13)C(=O)O)nc(-c1ccoc1)n2C1CCCCC1

HCID16727481

未命名化合物

PROCEDURE

实验过程

1-Cyclohexyl-2-furan-3-yl-6-methyl-1H-benzimidazole-5-carboxylic acid was coupled to 5-hydroxy-(S)-tryptophan methyl ester hydrochloride in the usual manner (Example 154). The material was then alkylated with methyl bromoacetate as described previously to give after deprotection by saponification and preparative C18 reversed-phase HPLC, the title compound of example 155.

WORKUP

后处理

customto give after deprotection by saponification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ee06f3081b804b0795c041cd178c20e1
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06794404B2
来源说明: uspto-grants-2004_09

反应 SMILES

[CH:1]1([N:7]2[C:11]3[CH:12]=[C:13]([CH3:19])[C:14]([C:16](O)=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:20]2[CH:24]=[CH:23][O:22][CH:21]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.C[O:27][C:28](=[O:42])[C@H:29]([CH2:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[C:38]([OH:41])[CH:39]=2)[NH:34][CH:33]=1)[NH2:30].Br[CH2:44][C:45]([O:47]C)=[O:46]>>[C:45]([CH2:44][O:41][C:38]1[CH:39]=[C:40]2[C:35](=[CH:36][CH:37]=1)[NH:34][CH:33]=[C:32]2[CH2:31][C@H:29]([NH:30][C:16]([C:14]1[C:13]([CH3:19])=[CH:12][C:11]2[N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C:8]([C:20]3[CH:24]=[CH:23][O:22][CH:21]=3)=[N:9][C:10]=2[CH:15]=1)=[O:17])[C:28]([OH:27])=[O:42])([OH:47])=[O:46]