反应详情

Benzofuran-2-yl methyl ketone (1.60 g, 10 mM) was dissolved in ether (20 mL). Under stirring of the mixture at room temperature, bromine (1.60 g) was added thereto. The resultant mixture was stirred for 10 minutes at room temperature, and poured in saturated sodium hydrogencarbonate solution, followed by extraction with ether (80 mL). The extract was washed with saturated brine and dried over magnesium sulfate, and the solvent was removed. Hexane was added to the residue and crystals were collected through filtration. The crystals were washed with hexane and dried, whereby 1.55 g of the product of interest was obtained (yield 69.4%).

1. extractionfollowed by extraction with ether (80 mL)
2. washThe extract was washed with saturated brine
3. dry with materialdried over magnesium sulfate
4. customthe solvent was removed
5. additionHexane was added to the residue and crystals
6. filtrationwere collected through filtration
7. washThe crystals were washed with hexane
8. customdried