Hydrochloric Acid → HCID 22666567, compound

Participants

Reaction Steps

In 4.25 mL of ethyl acetate is dissolved 0.85 g of 2-{[2-(2-benzo[b]thiophen-4-ylethoxy)ethyl]-(methyl)amino}-1-ethanol, to which is added 1.1 mL of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour and then at 5° C. for one hour. The reaction mixture is diluted with 10 mL of diisopropyl ether, and the deposited crystal is collected by filtration, washed with diisopropyl ether and dried. Thus, 0.81 g of 2-[[2-(2-benzo[b]thiophen-4-ylethoxy)ethyl](methyl)-amino)-1-ethanol hydrochloride is obtained.

Provenance & Evidence