Hydrochloric Acid → HCID 22666567, compound

HRID 1007908Notes

Reaction equation

HRID 1007908 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:7][CH:8]=[CH:9][C:2]1=2.[ClH:20]>C(OCC)(=O)C.C(OC(C)C)(C)C>[ClH:20].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666421HCID 22666421, compound

Product 1

HCID 22666567HCID 22666567, compound

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

In 4.25 mL of ethyl acetate is dissolved 0.85 g of 2-{[2-(2-benzo[b]thiophen-4-ylethoxy)ethyl]-(methyl)amino}-1-ethanol, to which is added 1.1 mL of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour and then at 5° C. for one hour. The reaction mixture is diluted with 10 mL of diisopropyl ether, and the deposited crystal is collected by filtration, washed with diisopropyl ether and dried. Thus, 0.81 g of 2-[[2-(2-benzo[b]thiophen-4-ylethoxy)ethyl](methyl)-amino)-1-ethanol hydrochloride is obtained.

Workup

  1. waitat 5° C. for one hour
  2. filtrationthe deposited crystal is collected by filtration
  3. washwashed with diisopropyl ether
  4. customdried

Sources & evidence

ORD record
ord-6cee10f9b50648e9a1f63cb5af623468
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

Loading…