Oxalic Acid → HCID 22666422, compound

HRID 1007912Notes

Reaction equation

HRID 1007912 reaction equation
[F:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][O:13][CH2:14][CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][OH:19])=[CH:10][C:4]=2[CH:3]=1.[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23]>C(OCC)(=O)C>[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23].[F:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][O:13][CH2:14][CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][OH:19])=[CH:10][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 22666333HCID 22666333, compound

Product 1

HCID 22666422HCID 22666422, compoundYield 80.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

In 1 mL of ethyl acetate is dissolved 0.58 g of 2-[{2-[2-(2-fluorobenzo[b]thiophen-5-yl)ethoxy]-ethyl}-(methyl)amino]-1-ethanol, to which is added 1 mL of a solution of 0.18 g of oxalic acid in ethyl acetate. The mixture is stirred at ambient temperature for 2 hours. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.61 g of 2-[{2-[2-(2-fluorobenzo[b]-thiophen-5-yl)ethoxy]ethyl}(methyl)amino]-1-ethanol oxalate.

Workup

  1. filtrationThe deposited crystal is collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-b708e3132ad3431ca054307d25e57601
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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