Hydrochloric Acid → HCID 22666370, compound

Participants

Reaction Steps

In 2.9 mL of ethyl acetate is dissolved 0.48 g of 2-[{2-[2-(6-fluorobenzo[b]thiophen-7-yl)ethoxy]ethyl}-(methyl)amino]-1-ethanol, to which is added 0.57 mL of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour. The reaction mixture is diluted with 5 mL of diisopropyl ether and stirred at ambient temperature for one hour. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.45 g of 2-[{2-[2-(6-fluorobenzo[b]thiophen-7-yl)ethoxy]ethyl}(methyl)-amino]-1-ethanol hydrochloride.

Provenance & Evidence