Hydrochloric Acid → HCID 22666370, compound

HRID 1007913Notes

Reaction equation

HRID 1007913 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[CH2:11][CH2:12][O:13][CH2:14][CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][OH:19].[ClH:21]>C(OCC)(=O)C.C(OC(C)C)(C)C>[ClH:21].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[CH2:11][CH2:12][O:13][CH2:14][CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][OH:19]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666371HCID 22666371, compound

Product 1

HCID 22666370HCID 22666370, compound

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

In 2.9 mL of ethyl acetate is dissolved 0.48 g of 2-[{2-[2-(6-fluorobenzo[b]thiophen-7-yl)ethoxy]ethyl}-(methyl)amino]-1-ethanol, to which is added 0.57 mL of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour. The reaction mixture is diluted with 5 mL of diisopropyl ether and stirred at ambient temperature for one hour. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.45 g of 2-[{2-[2-(6-fluorobenzo[b]thiophen-7-yl)ethoxy]ethyl}(methyl)-amino]-1-ethanol hydrochloride.

Workup

  1. stirringstirred at ambient temperature for one hour
  2. filtrationThe deposited crystal is collected by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-35c03e233b7c4faba337c6d671732739
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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