Thionyl Chloride → HCID 22666474, compound

HRID 1007931Notes

Reaction equation

HRID 1007931 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][CH2:12][O:13][CH2:14][CH2:15]O)=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[ClH:19].[Cl:19][CH2:15][CH2:14][O:13][CH2:12][CH2:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][CH:3]=[N:4]2

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22666263HCID 22666263, compound

Product 1

HCID 22666474HCID 22666474, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In 10 mL of benzene is dissolved 0.73 g of 2-[2-(6-quinoxalinyl)ethoxy]-1-ethanol, to which is added 0.32 mL of thionyl chloride. The mixture is heated under reflux for 30 minutes. The solvent is distilled off and the deposited crystal is collected by filtration to obtain 0.37 g of 6-[2-(2-chloroethoxy)-ethyl]-quinoxaline hydrochloride.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 30 minutes
  3. distillationThe solvent is distilled off
  4. filtrationthe deposited crystal is collected by filtration

Sources & evidence

ORD record
ord-e0349c1878ee4dbe9093006211846655
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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