Dimethylsulphamoyl chloride → N'-{2-[2-(4-Amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethoxy)ethyl}-N,N-dimethylsulfamide

HRID 1008035Notes

Reaction equation

[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[NH2:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][N:14]1[C:22]2[C:21]([CH3:23])=[C:20]([CH3:24])[N:19]=[C:18]([NH2:25])[C:17]=2[N:16]=[C:15]1[CH3:26]>>[NH2:25][C:18]1[C:17]2[N:16]=[C:15]([CH3:26])[N:14]([CH2:13][CH2:12][O:11][CH2:10][CH2:9][NH:8][S:3]([N:2]([CH3:7])[CH3:1])(=[O:5])=[O:4])[C:22]=2[C:21]([CH3:23])=[C:20]([CH3:24])[N:19]=1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 219130531-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 21913134N'-{2-[2-(4-Amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethoxy)ethyl}-N,N-dimethylsulfamide

Procedure

Using the method of Examples 34-50, dimethylsulfamoyl chloride was reacted with 1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The product was purified using Method A. The observed accurate mass was 371.1861.

Sources & evidence

ORD record: ord-806dda5854fd42de9d43d59982d63deb
Source dataset: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06797718B2

Reaction notes

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