Piperidine → HCID 67281560, compound

HRID 1008209Notes

Reaction equation

HRID 1008209 reaction equation
[CH3:1][C:2]1[C:10]([S:11]([NH:14][CH3:15])(=[O:13])=[O:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:16])[NH:6]2.[CH2:17]([O:19][C:20](=[O:33])[CH2:21][NH:22][C:23]([C:25]1[C:29]([CH3:30])=[C:28]([CH:31]=O)[NH:27][CH:26]=1)=[O:24])[CH3:18].N1CCCCC1>C(O)C>[CH2:17]([O:19][C:20](=[O:33])[CH2:21][NH:22][C:23]([C:25]1[C:29]([CH3:30])=[C:28]([CH:31]=[C:4]2[C:3]3[C:7](=[CH:8][CH:9]=[C:10]([S:11](=[O:12])(=[O:13])[NH:14][CH3:15])[C:2]=3[CH3:1])[NH:6][C:5]2=[O:16])[NH:27][CH:26]=1)=[O:24])[CH3:18]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 690525894-Methyl-5-methylaminosulfonyl-2-oxindoleHCID 85786887HCID 85786887, compound

Product 1

HCID 67281560HCID 67281560, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Methyl-5-methylaminosulfonyl-2-oxindole (50 mg, 0.21 mmol) was condensed with [(5-formyl-4-methyl-1H-pyrrole-3-carbonyl)-amino]-acetic acid ethyl ester (100 mg, 0.42 mmol) and piperidine (0.1 mL) in ethanol (2 mL) to give 50 mg (52%) of the title compound.

Sources & evidence

ORD record
ord-aed9dff1be6c43ca88a3a5271c9cb588
Source dataset
uspto-grants-2004_09
Patent number
US06797725B2

Reaction notes

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