反应详情

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluoroaniline (100 mg) was dissolved in chloroform (5 ml) and triethylamine (1 ml), and a solution of triphosgene (104 mg) in dichloromethane was then added to the solution. The mixture was heated under reflux for 5 min. Next, sec-butylamine (48 μl) was added to the reaction solution. The mixture was heated under reflux for 10 min. The solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography on silica gel by development with chloroform/acetone (8/2) to give 117 mg (yield 89%) of the title compound.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 5 min
3. temperatureThe mixture was heated
4. temperatureunder reflux for 10 min
5. customThe solvent was removed by distillation under the reduced pressure
6. customThe residue was purified by chromatography on silica gel by development with chloroform/acetone (8/2)