4-Methylpiperidine → HCID 22665800, compound

HRID 1008490Notes

Reaction equation

[ClH:1].CO[C:4](=[O:32])[CH:5]([NH:18][S:19]([C:22]1[CH:31]=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=1)(=[O:21])=[O:20])[CH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([NH2:17])=[N:12][CH:11]=[CH:10]2.[CH3:33][CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[ClH:1].[NH2:17][C:13]1[C:14]2[C:9](=[CH:8][C:7]([CH2:6][CH:5]([NH:18][S:19]([C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=3)(=[O:21])=[O:20])[C:4]([N:37]3[CH2:38][CH2:39][CH:34]([CH3:33])[CH2:35][CH2:36]3)=[O:32])=[CH:16][CH:15]=2)[CH:10]=[CH:11][N:12]=1

Participants

Reactant 2

HCID 693814-Methylpiperidine

HCID 69781962HCID 69781962, compound

Product 1

HCID 22665800HCID 22665800, compound

Procedure

Compound 11a was saponified and subsequently coupled with 4-methylpiperidine using the procedure described for 4 to give 11b. 1H-NMR 200 MHz (CD3OD) δ: 0.15-3.24 (12H, m), 3.75-4.24 (2H, m), 4.57-4.72 (1H, m), 6.71-7.91 (10H, m), 8.11-8.19 (2H, m)

Sources & evidence

ORD record: ord-73551810566249a69c8f1b8649cdf3ac
Source dataset: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06797710B2

Reaction notes

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