N-(6-formyl-1-isoquinolinyl)benzamide → N-(7-Formylisoquinolinyl)benzamide

HRID 1008498Notes

Reaction equation

HRID 1008498 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[CH:21](C1C=C2C(=CC=1)C(NC(=O)C1C=CC=CC=1)=NC=C2)=[O:22]>>[CH:21]([C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1)=[O:22]

Participants

3

Reactant 2

HCID 22665740N-(6-formyl-1-isoquinolinyl)benzamideHCID 22665843N-(7-bromo-1-isoquinolinyl)benzamide

Product 1

HCID 22665912N-(7-Formylisoquinolinyl)benzamide

Procedure

N-(7-Formylisoquinolinyl)benzamide was prepared from 37e using the procedure described for 1f but was not purified using column chromatography. The crude aldehyde was transformed into the title compound using the procedure described for 1g folowed by purification using column chromatography on silica gel (toluene/ethyl acetate: 2/1). M.p. 137.5-139.0° C.

Workup

  1. customwas not purified
  2. customfolowed by purification

Sources & evidence

ORD record
ord-e1615c706a074bc99a7aa1cd7ba2a707
Source dataset
uspto-grants-2004_09
Patent number
US06797710B2

Reaction notes

Loading…