Sulfuryl chloride → 7-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

HRID 1008538Notes

Reaction equation

HRID 1008538 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[S:14](Cl)([Cl:17])(=[O:16])=[O:15].COC1C=C2C(CCN(S(Cl)(=O)=O)C2)=CC=1>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:12][CH2:11][CH2:10][N:9]([S:14]([Cl:17])(=[O:16])=[O:15])[CH2:8][C:7]=2[CH:13]=1

Participants

5

Reactant 3

HCID 24648Sulfuryl chlorideHCID 226656767-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chlorideHCID 226658207-Methoxy-2,3,4,5-tetrahydro-1,4-benzoxazepine

Product 1

HCID 226656217-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was prepared from 1.4 g of 7-methoxy-2,3,4,5-tetrahydro-benzo[f][1,4]-oxazepine, 0.91 mL of sulfuryl chloride and 4.7 mL of triethylamine using the procedure described for 63f. Yield: 0.23 g (oil), EI-MS: 277 (M+).

Sources & evidence

ORD record
ord-fb63b4728118422293e93903b6c8ea38
Source dataset
uspto-grants-2004_09
Patent number
US06797710B2

Reaction notes

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