HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → n-(1-Amino-isoquinolin-6-ylmethyl)-azetidin-2(s)-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-(1-Amino-isoquinolin-6-ylmethyl)-1-tert.butoxycarbonyl-azetidin-2(S)-carboxamide | HCID 22958561 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | n-(1-Amino-isoquinolin-6-ylmethyl)-azetidin-2(s)-carboxamide | HCID 22969261 | 121.7% |
Reaction Steps
10 mL Trifluoroacetic acid was added to a solution of 2,4 g of N-(1-amino-isoquinolin-6-ylmethyl)-1-tert.butoxycarbonyl-azetidin-2(S)-carboxamide in 5.0 mL dichloromethane. The solvent was removed i.vac to give 2.1 g of the title compound as trifluoroacetate salt. MS: 371.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797710B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-6ce8b70db32e4c548ebe19170d4f1325 |
| Source note | uspto-grants-2004_09 |