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HRID1008598

反应详情

EQUATION

反应方程式

HRID 1008598 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N1CC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1
HCID22958561

未命名化合物

PRODUCTS

生成物

1
结构：Nc1nccc2cc(CNC(=O)[C@@H]3CCN3)ccc12
HCID22969261

未命名化合物

收率 121.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

10 mL Trifluoroacetic acid was added to a solution of 2,4 g of N-(1-amino-isoquinolin-6-ylmethyl)-1-tert.butoxycarbonyl-azetidin-2(S)-carboxamide in 5.0 mL dichloromethane. The solvent was removed i.vac to give 2.1 g of the title compound as trifluoroacetate salt. MS: 371.

WORKUP

后处理

  1. customThe solvent was removed i.vac