Formaldehyde → HCID 23154243, compound

HRID 1008747Notes

Reaction equation

HRID 1008747 reaction equation
[OH-].[Na+].[CH2:3]([CH:7]([CH2:10][CH2:11][CH2:12][CH3:13])[CH:8]=[O:9])[CH2:4][CH2:5][CH3:6].C=O.C[CH2:17][O:18]CC>CO.O>[CH2:3]([C:7]([CH2:17][OH:18])([CH2:10][CH2:11][CH2:12][CH3:13])[CH:8]=[O:9])[CH2:4][CH2:5][CH3:6]

Participants

7

Reactant 4

HCID 712FormaldehydeHCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 3341006Di-n-butylacetaldehyde

Product 1

HCID 23154243HCID 23154243, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

An aqueous solution of 1 N sodium hydroxide (150 mL) was added dropwise to a solution of 209 g of dibutylacetaldehyde (supplied from Aldrich) and 127 g of an aqueous solution of 35% formalin (supplied from Wako Pure Chemical Industries) in 1500 mL of methanol under ice cooling, and stirred at room temperature overnight. Then 2 L of ether and 2 L of water were added to the reaction solution, and the mixture was separated into two liquid phases. The organic layer was dried on sodium sulfate anhydrate and concentrated, to yield 248 g of the title compound.

Workup

  1. customthe mixture was separated into two liquid phases
  2. customThe organic layer was dried on sodium sulfate anhydrate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a716cfce9e1e4aaba5aaa0d6a86a1b9b
Source dataset
uspto-grants-2011_07
Patent number
US07973030B2

Reaction notes

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