Formaldehyde → HCID 23154243, compound

Participants

Reaction Steps

An aqueous solution of 1 N sodium hydroxide (150 mL) was added dropwise to a solution of 209 g of dibutylacetaldehyde (supplied from Aldrich) and 127 g of an aqueous solution of 35% formalin (supplied from Wako Pure Chemical Industries) in 1500 mL of methanol under ice cooling, and stirred at room temperature overnight. Then 2 L of ether and 2 L of water were added to the reaction solution, and the mixture was separated into two liquid phases. The organic layer was dried on sodium sulfate anhydrate and concentrated, to yield 248 g of the title compound.

Provenance & Evidence