Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → Methyl 2-benzylideneaminohexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Methyl norleucinate--hydrogen chloride (1/1) | HCID 14039064 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 2-benzylideneaminohexanoate | HCID 23074255 | 100% |
반응 단계
Triethylamine (8.67 g) (supplied from Wako Pure Chemical Industries), 7.74 g of magnesium sulfate anhydrate and 4.55 g of benzaldehyde (supplied from Wako Pure Chemical Industries) were added to a suspension of 7.79 g of methyl 2-aminohexanoate hydrochloride (supplied from BACHEM) in 70 mL of dichloromethane, and stirred at room temperature overnight. The reaction suspension was filtrated and the filtrate was concentrated. Then 280 mL of ether was added to the residue. The resulting suspension was filtrated and the filtrate was concentrated. Again 280 mL of ether was added to the residue, and the filtration and the concentration were repeated in the same manner, to yield 10.0 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07973030B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-639ced958a1f4de2843dc1857d1dde87 |
| 출처 메모 | uspto-grants-2011_07 |