反应详情

Triethylamine (8.67 g) (supplied from Wako Pure Chemical Industries), 7.74 g of magnesium sulfate anhydrate and 4.55 g of benzaldehyde (supplied from Wako Pure Chemical Industries) were added to a suspension of 7.79 g of methyl 2-aminohexanoate hydrochloride (supplied from BACHEM) in 70 mL of dichloromethane, and stirred at room temperature overnight. The reaction suspension was filtrated and the filtrate was concentrated. Then 280 mL of ether was added to the residue. The resulting suspension was filtrated and the filtrate was concentrated. Again 280 mL of ether was added to the residue, and the filtration and the concentration were repeated in the same manner, to yield 10.0 g of the title compound.

1. filtrationThe reaction suspension was filtrated
2. concentrationthe filtrate was concentrated
3. additionThen 280 mL of ether was added to the residue
4. filtrationThe resulting suspension was filtrated
5. concentrationthe filtrate was concentrated
6. additionAgain 280 mL of ether was added to the residue
7. filtrationthe filtration
8. concentrationthe concentration