反应详情

温度

60 °C

A solution (0.1 M) of methyl 3-methyl-N-({[(1R,2R)-2-pent-4-en-1-ylcyclopropyl]oxy}carbonyl)-L-valinate in 2:1 mixture of MeOH/H2O was treated with LiOH.H2O (4 eq) and then heated at 60° C. for 4 h. The mixture was cooled and concentrated to half volume, then diluted with EtOAc and acidified with aqueous HCl (1 N). The organic layer was separated and washed with brine then dried. Removal of the volatiles afforded the title compound (98%) as an oil. MS (ES+) m/z 284 (M+H)+

1. temperatureThe mixture was cooled
2. concentrationconcentrated to half volume
3. additiondiluted with EtOAc
4. customThe organic layer was separated
5. washwashed with brine
6. customthen dried
7. customRemoval of the volatiles