反应详情

A solution, cooled to 0° C., of 1.1 g (3 mmol) of 4-nitrophenyl 2-(methylamino)-2-oxoethyl carbonate, prepared in step 3.1., in 10 ml of 1,2-dichloroethane is admixed dropwise at about 0° C. with a solution of 0.53 g (2.85 mmol) of 1,1-dimethylethyl piperazine-1-carboxylate in 5 ml of 1,2-dichloroethane. Stirring is continued at 0° C. for 1 hour, then at ambient temperature for 3 hours.

1. customprepared in step 3.1
2. waitat ambient temperature for 3 hours