反应详情

To a mixture containing 6,8-dibromochroman-4-one in acetonitrile (0.3M) and 5/2 formic acid/triethylamine (30% by volume) was added (1S,2S)-(+)-N-p-tosyl-1,2-diphenylethylene diamine (1 mol %) and dichloro(p-cymene)-ruthenium (II) dimer (0.5 mol %). After stirring for 24 h, the reaction was diluted with ethylacetate and washed with brine/sodium bicarbonate (1:1). The organic phase was concentrated under reduced pressure to afford the title compound as a tan solid.

1. washwashed with brine/sodium bicarbonate (1:1)
2. concentrationThe organic phase was concentrated under reduced pressure