HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[({4-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]phenyl}amino)carbonyl]cyclopentanaminium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (E)-ethyl 3-(4-(1-(tert-butoxycarbonylamino)cyclopentanecarboxamido)phenyl)acrylate | HCID 59016322 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[({4-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]phenyl}amino)carbonyl]cyclopentanaminium chloride | HCID 86629780 | — |
Reaction Steps
Ethyl (2E)-3-{4-[({1-[(tert-butoxycarbonyl)amino]cyclopentyl}carbonyl)amino]phenyl}acrylate (from Step 1) was dissolved in CH2Cl2 (0.5 M) and an excess of hydrogen chloride in diethyl ether (2.0 M) was added. The solution was left stirring overnight at RT. The precipitate formed was filtered off and dried in vacuo. A colourless solid was obtained (99%), which was used without further characterisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973026B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-2997948f9b7944189f96ea77645f4ece |
| Source note | uspto-grants-2011_07 |