Hydrochloric Acid → HCID 42635619, compound

HRID 1009012Notes

Reaction equation

HRID 1009012 reaction equation
C1(S([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[O:19][CH3:20])[C:12]([S:21]([NH:24][C:25](=[O:33])[NH:26][C:27]3[S:28][C:29]([Br:32])=[CH:30][N:31]=3)(=[O:23])=[O:22])=[CH:11]2)(=O)=O)C=CC=CC=1.[OH-].[Na+].Cl>>[Br:32][C:29]1[S:28][C:27]([NH:26][C:25]([NH:24][S:21]([C:12]2[C:13]3[C:18](=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][CH:14]=3)[NH:10][CH:11]=2)(=[O:22])=[O:23])=[O:33])=[N:31][CH:30]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86630945HCID 86630945, compound

Product 1

HCID 42635619HCID 42635619, compound

Conditions

Temperature
70 °C

Procedure

A suspension of 1-(benzenesulfonyl)-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-7-methoxy-1H-indole-3-sulfonamide (cf. Ex. 43iii), 0.072 g) in 1 n sodium hydroxide (5 mL) was heated to 70° C. for 4 h. The reaction mixture was cooled down and acidified with 1N HCl to pH 4-5. The precipitate was filtered off, washed with water and dried to obtain the title compound as light brown solid. MS (ISN): m/e 429.3, 431.3 (M−H)−

Workup

  1. temperatureThe reaction mixture was cooled down
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5b1efb7bda9b49abb984f8bc74b0498a
Source dataset
uspto-grants-2011_07
Patent number
US07973051B2

Reaction notes

Loading…