反应详情

To a solution of 4-bromo-2-methyl-thiophene (1.594 g, 9.00 mmol) in 5.0 mL of diethyl ether was added dropwise 2.1 mL of tert-butyllithium in pentane (1.7 M, 09 eq.). After stirring for 20 Min. at −78° C., sulfur dioxide (condensed, ca. 4 mL) was added dropwise and the reaction mixture kept for another 30 min at this temperature. The dry ice cooling bath was removed and the reaction mixture diluted with heptane; the precipitated solid was collected, washed with some heptane and dried at high vacuum to yield 1.100 g of the title compound as white solid.

1. customThe dry ice cooling bath was removed
2. additionthe reaction mixture diluted with heptane
3. customthe precipitated solid was collected
4. washwashed with some heptane
5. customdried at high vacuum