反应详情

The above prepared 4-ethyl-5-ethynyl-thiazol-2-ylamine (0.255 g, 1.675 mmol) was dissolved in 8 mL of ethyl acetate and hydrogenated over 0.125 g of Pd on charcoal (10%) at atmospheric pressure and ambient temperature over night. Filtration over a pad of Ceite and evaporation off all solvents, followed by flash chromatography (SiO2, hexane/ethyl acetate=6/4), yielded 0.184 g of the title product as light yellow solid.

1. filtrationFiltration
2. customover a pad of Ceite and evaporation off all solvents