反应详情

温度

57.5 °C

To a solution of 2-bromo-1-phenyl-propan-1-one (3.64 g, 17.1 mmol) in 30 mL of ethanol was added thiourea (1.30 g, 1.00 eq.) and the mixture vigorously stirred at 55-60° C. for 4 h. Pouring onto crashed ice/Na2CO3, twofold extraction with ethyl acetate, washing with water and brine, drying over sodium sulfate, and evaporation of the solvents, followed by crystallization from ethyl acetate/hexane, left 2.87 g of the title product as off-white crystals.

1. additionPouring
2. extractionice/Na2CO3, twofold extraction with ethyl acetate
3. washwashing with water and brine
4. dry with materialdrying over sodium sulfate, and evaporation of the solvents
5. customfollowed by crystallization from ethyl acetate/hexane
6. waitleft 2.87 g of the title product as off-white crystals