Hydrochloric Acid → HCID 24852563, compound

HRID 1009353Notes

Reaction equation

HRID 1009353 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]3[CH2:15][CH2:16][CH2:17]/[C:18](=[CH:19]\[C:20]4[CH:25]=[CH:24][C:23]([N:26]5[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]5)=[C:22]([O:32][CH3:33])[CH:21]=4)/[C:13]3=[N:12][C:11]=2[C:34]([O:36]C)=[O:35])=[CH:6][CH:5]=1.Cl>CO>[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]3[CH2:15][CH2:16][CH2:17]/[C:18](=[CH:19]\[C:20]4[CH:25]=[CH:24][C:23]([N:26]5[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]5)=[C:22]([O:32][CH3:33])[CH:21]=4)/[C:13]3=[N:12][C:11]=2[C:34]([OH:36])=[O:35])=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24852455HCID 24852455, compound

Product 1

HCID 24852563HCID 24852563, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 2 N sodium hydroxide solution (1 mL) was added to a solution of methyl 3-(4-fluorophenyl)-8-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylate (172 mg) in methanol (4 mL), and the reaction solution was heated under reflux for nine hours. The reaction solution was left to cool to room temperature, and 2 N hydrochloric acid (1 mL) was added to the reaction solution. The solid precipitated in the reaction solution was collected by filtration and washed with diethyl ether to obtain 167 mg of the title compound. The property value of the compound is as follows.

Workup

  1. temperaturethe reaction solution was heated
  2. temperatureunder reflux for nine hours
  3. waitThe reaction solution was left
  4. customThe solid precipitated in the reaction solution
  5. filtrationwas collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-304d55c354994938be24e1ff90b2a177
Source dataset
uspto-grants-2011_07
Patent number
US07973033B2

Reaction notes

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