Hydrochloric Acid → HCID 67067248, compound

HRID 1009442Notes

Reaction equation

HRID 1009442 reaction equation
[OH-].[Na+].[Cl:3][CH2:4][CH2:5][CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=1)[C:8]([O:10]C)=[O:9].Cl>CO>[Cl:3][CH2:4][CH2:5][CH2:6][CH:7]([C:12]1[CH:13]=[CH:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=1)[C:8]([OH:10])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67067427HCID 67067427, compound

Product 1

HCID 67067248HCID 67067248, compoundYield 191.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 5 N sodium hydroxide solution (0.5 mL) was added to a solution of methyl 5-chloro-2-(4-dimethylaminophenyl)pentanoate (175 mg) in methanol (2 mL), and the reaction solution was stirred at room temperature for 23.5 hours. Thereafter, 1 N aqueous hydrochloric acid (2.5 mL) was added to the reaction solution, and the reaction solution was concentrated under reduced pressure to obtain 317 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fd68bbab442f420a8583b6fbe98cd0ec
Source dataset
uspto-grants-2011_07
Patent number
US07973033B2

Reaction notes

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