Hydrogen chloride-ethyl acetate → HCID 67304349, compound

Participants

Reaction Steps

2.59 g of 3-{[bis(tert-butoxycarbonyl)amino]methyl}-4-fluorobenzoic acid was dissolved in 10.0 mL of ethyl acetate, and 10.0 mL of a 4 M hydrogen chloride/ethyl acetate solution was added thereto, followed by stirring at room temperature for 4 hours. The reaction liquid was concentrated under reduced pressure, and the obtained residue was crystallized by addition of ethyl acetate and hexane to obtain 2.59 g of ethyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride.

Provenance & Evidence