Hydrogen chloride-ethyl acetate → HCID 67304349, compound

HRID 1009472Notes

Reaction equation

HRID 1009472 reaction equation
C(OC([N:8]([CH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[F:26])[C:20]([OH:22])=[O:21])C(OC(C)(C)C)=O)=O)(C)(C)C.[ClH:27].[C:28](OCC)(=O)[CH3:29]>C(OCC)(=O)C>[ClH:27].[NH2:8][CH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[F:26])[C:20]([O:22][CH2:28][CH3:29])=[O:21]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67304775HCID 67304775, compound

Product 1

HCID 67304349HCID 67304349, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2.59 g of 3-{[bis(tert-butoxycarbonyl)amino]methyl}-4-fluorobenzoic acid was dissolved in 10.0 mL of ethyl acetate, and 10.0 mL of a 4 M hydrogen chloride/ethyl acetate solution was added thereto, followed by stirring at room temperature for 4 hours. The reaction liquid was concentrated under reduced pressure, and the obtained residue was crystallized by addition of ethyl acetate and hexane to obtain 2.59 g of ethyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride.

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customthe obtained residue was crystallized by addition of ethyl acetate and hexane

Sources & evidence

ORD record
ord-abec6d6fe02147ae9ab15354dfa68f36
Source dataset
uspto-grants-2011_07
Patent number
US07973078B2

Reaction notes

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