Trimethylsilylacetylene → 2-Chloro-5-(2-methyl-4-trimethylsilanylethynyl-imidazol-1-yl)-pyridine

HRID 1009730Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11](I)[N:10]=[C:9]2[CH3:14])=[CH:4][N:3]=1.[CH3:15][Si:16]([C:19]#[CH:20])([CH3:18])[CH3:17]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:20]#[C:19][Si:16]([CH3:18])([CH3:17])[CH3:15])[N:10]=[C:9]2[CH3:14])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 860124392-Chloro-5-(4-iodo-2-methyl-imidazol-1-yl)-pyridine

Product 1

HCID 865953252-Chloro-5-(2-methyl-4-trimethylsilanylethynyl-imidazol-1-yl)-pyridine

Procedure

The title compound, MS: m/e=290.6 (M+H+), was prepared in accordance with the general method of example B, step 1, from 2-chloro-5-(4-iodo-2-methyl-imidazol-1-yl)-pyridine and trimethylsilylacetylen.

Sources & evidence

ORD record: ord-67504567c66d4b7ab6916097e1c2c959
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07973165B2

Reaction notes

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