反应详情

4-p-Tolyl-thiazol-2-ylamine (38.1 mg, 0.200 mmol) and 4-methyl-benzoyl chloride (30.9 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was stirred overnight at room temperature. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (13.5 mg, 0.0438, 21.9%). ESI-MS m/z calc. 308.1, found 309.0 (M+1)+ Retention time 3.72 minutes.

1. filtrationThe crude product was filtered
2. customevaporated to dryness
3. dissolutiondissolved in 1 mL of dimethylsulfoxide
4. custompurified by reverse-phase preparative liquid chromatography (13.5 mg, 0.0438, 21.9%)